RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
HMOX1
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
DNA methylation correlations in CF cells; DNA methylation analysis in NEC; DNA methylation at HMOX1 was not associated with nearby polymorphisms etc.
Target
NA
Pathway
NA
PubMed ID
Title
DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis
Year
2017
Function
DNA methylation levels are altered in nasal epithelial and blood cell samples from CF patients. Analysis of CFTR and 13 lung disease modifier genes shows DNA methylation changes of small magnitude: some of them are a consequence of the disease; Other changes may result in small expression variations that collectively modulate the lung disease severity. Three genes were differentially methylated in CF patients compared with controls and/or in groups of pulmonary severity: HMOX1 and GSTM3 in nasal epithelial samples; HMOX1 and EDNRA in blood samples. The association between pulmonary severity and DNA methylation at EDNRA was confirmed in blood samples from an independent set of CF patients.